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The well-known drug Viagra is primarily used to treat erectile dysfunction (ED) in men. Its active ingredient, sildenafil citrate, relaxes blood vessels and increases blood flow to the penis, which facilitates an erection when combined with sexual stimulation. Formulated by Pfizer and approved by the U.S. Food and Drug Administration in 1998, Viagra changed the way ED is treated and gave hope to millions of men around the world. Prior to Viagra, there were few and frequently invasive treatment options for ED, so the introduction of an effective oral medication was a major advancement in sexual health.