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A prescription opioid analgesic called tapentadol is used to treat moderate to severe pain. Its analgesic effects are enhanced by its dual method of binding to µ-opioid receptors and blocking norepinephrine reuptake. It works well for both nociceptive and neuropathic pain because of its special activity. Both immediate-release and extended-release forms of tapentadol are available; the latter is recommended for chronic pain that needs to be managed over an extended period of time.

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