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Common side effects of Tramadol include nausea, dizziness, dry mouth, constipation, and drowsiness. In higher doses, it can cause confusion, seizures, and respiratory depression, especially when combined with other central nervous system depressants like alcohol. Long-term use may lead to physical dependence and withdrawal symptoms upon stopping. Due to these risks, Tramadol should only be taken as prescribed and never combined with other sedatives without medical advice.