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Tapentadol is a prescription opioid analgesic used to treat moderate to severe pain, such as that from injury or surgery. It works by binding to opioid receptors in the brain, while also inhibiting the reuptake of norepinephrine, providing pain relief through two mechanisms. Tapentadol is available in immediate-release and extended-release forms. Common side effects include nausea, dizziness, constipation, and headache. Serious risks include respiratory depression, dependence, and overdose, particularly when misused or combined with other substances like alcohol.

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